Liver transplantation is the main therapeutic option for patients with end-stage liver disease. However, several acute complications can occur during transplant surgery, including acid-base disorder, coagulopathy and the need for massive blood transfusion. These complications compromise the transplant prognosis.
A scientific initiation research carried out at Unicamp with 95 patients undergoing liver transplantation at the Hospital de Clínicas (HC) between 2016 and 2018 sought to evaluate whether the occurrence of metabolic acidosis worsens coagulation disorders and leads to a greater need for transfusions during the intraoperative period of the transplant. of liver.
The study called Association of acid-base balance disorders with coagulation changes and transfusion requirements during liver transplantation was awarded as the best work in Hemotherapy presented during the Congress of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy (HEMO 2019), which took place in November last year in Rio de Janeiro.
“The association of acid-base disorder with coagulopathy and transfusion requirements is well studied in cases of severe polytrauma. However, this association has not been established in orthotopic liver transplantation”, comments Júlia Ruete de Souza, fourth-year Medicine student at PUC-Campinas and main author of the research.
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